Specific autoantibodies in patients with longstanding CRPS

We recently published a study on antibodies found in the blood of patients with longstanding Complex Regional Pain Syndrome [1].

Antibodies are substances produced by the body’s immune system. Their best-known role is to fight infection. However sometimes they go wrong, and bind to the body’s own cells, causing dysfunction or damage. These latter types of antibodies, which bind to body cells are termed autoantibodies.

Our recent study shows that most patients with longstanding CRPS have special types of autoantibodies in their blood. In contrast, these autoantibodies were not found in healthy volunteers, patients with fibromyalgia, neuropathic pain, or ‘myasthenia gravis’, an immune disease.

We already knew that special autoantibodies are produced by patients with recent onset CRPS [3][see Footnote]. Our new findings are relevant and important, because they demonstrate that autoantibodies are still being produced by people with CRPS as late as several years after injury, i.e. at a time when acute CRPS signs such as strong swelling and redness will have mellowed, and there is an expectation that the injury will have fully healed. The autoantibody presence in such longstanding CRPS shows that the patients’ immune systems remain abnormally activated.

The autoantibodies we identified were found to specifically activate the alpha1a receptor on cell surfaces. This particular receptor has previously been implicated in CRPS, and thus its activation might be relevant to the causes of CRPS. But there was something else – we initially thought that only those CRPS patients who responded to an immune treatment, intravenous immunoglobulin, would have autoantibodies, i.e. no more than 25% of all patients, see my Body in Mind blog August 2010. Yet, we found that, in fact a majority of all patients with longstanding CRPS had these specific autoantibodies in their blood. That meant that although only some patients with longstanding CRPS will respond to intravenous immunoglobulin a much larger group of of patients may have a specific immune dysregulation,.

How might these autoantibodies cause CRPS-related problems? Autoantibodies may bind either to nerve cells, or other cells situated close to nerves and may initiate abnormal sensory and/or motor nerve activation. An example of this type of autoantibody-nerve interaction is known as neuromyotonia, a neurological condition where different types of autoantibodies bind to peripheral motor nerves. The autoantibodies in neuromyotonia bind to the motor nerves and change ‘motor-nerve’ function, giving people abnormal muscle activations. It is thought that the autoantibodies in neuromyotonia may even cause (non-CRPS) neuropathic pain, which is a new field of research.

Having identified specific alpha 1a autoantibodies in patients’ blood, where do we go from here? We will look more closely at the CRPS immune dysregulation, and also investigate whether some immune procedures and drugs that work in other conditions can reduce CRPS pain. We have already conducted an audit [2], and have started a first trial to test this idea.

Our laboratory results on autoantibodies in longstanding CRPS are preliminary. We have yet to identify the molecular structure (i.e. the sequence of amino acids) against which these antibodies are directed – in fact our results suggest that the antibodies from different patients may bind to slightly different cell structures, having the common ultimate effect to activate alpha 1 receptors. We have also yet to develop a workable autoantibody blood test, as the test which we used is very cumbersome. Finally, but not least of all it will be important to convincingly show how these autoantibodies contribute to CRPS.

Nevertheless, I hope that these recent discoveries may eventually contribute to solve the riddle of what is causing CRPS after trauma, so that we can better treat those patients for whom currently no solution is available.

About Andreas Goebel

Andreas GoebelAndreas Goebel was born and raised in the Rhein/Main area in Southern Germany. He studied Medicine in Würzburg/Germany and started his training in Anaesthesiology and Pain Medicine at Würzburg Hospital; he also received a scholarship to study immunology at Harvard Medical School. Having returned to Germany things changed when Andreas met his Irish wife in the US and they ultimately decided to move to the UK. There, he continued his training, first attached to the Oxford rotation, then UCLH, and was appointed Consultant in Pain Medicine in 2007 at the Liverpool Walton Centre, the Country’s largest Pain Medicine department.

Andreas set up the first regional treatment network for Complex Regional Pain Syndrome, and also initiated and chaired the UK CRPS Guidance group, which published its comprehensive guidance in 2012). In 2008 he was appointed Assistant Professor (Senior Lecturer) in Pain Medicine at Liverpool University. Andreas’ chief research interest is in how the immune system, and specifically autoantibodies, may contribute to causing chronic pain and how this might translate into new treatments.


[1] Dubuis E, Thompson V, Leite MI, Blaes F, Maihofner C, Greensmith D, Vincent A, Shenker N, Kuttikat A, Leuwer M, Goebel A. Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoceptors. Pain 2014;155(11):2408-2417.

[2] Goebel A, Jones S, Oomman S, Callaghan T, Sprotte G. Treatment of long-standing complex regional pain syndrome with therapeutic plasma exchange: a preliminary case series of patients treated in 2008-2014. Pain Med 2014;15(12):2163-2164.

[3] Kohr D, Singh P, Tschernatsch M, Kaps M, Pouokam E, Diener M, Kummer W, Birklein F, Vincent A, Goebel A, Wallukat G, Blaes F. Autoimmunity against the beta(2) adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain 2011;152(12):2690-2700.


The autoantibodies identified in the acute setting included one type, antimuscarinic, which was likely also present in our samples, and another, anti-beta 2, which we did not detect. The laboratory method we used was different to that which was used to identify these acute-setting autoantibodies, however our method was sensitive to activating beta 2 antibodies, and thus should have picked them up had they been present in our samples. Their absence may be either due to geographically different patient populations (German vs. UK), the fact that the acute-setting tests used a immature cell type whereas we used adult cells, or because perhaps autoantibodies produced in the acute setting differ from those in the chronic setting. Of note, earlier investigations in the acute setting had not specifically looked for the new type of antibodies discovered now, so we don’t yet know whether these new antibodies are restricted to the chronic setting.


  1. Thank you for this summary of your findings – it’s really interesting to me as a person with CRPS. My doctor keeps finding ASMAs in my blood tests when I have flares, it’s the only basic AI marker he finds. Apparently these can only mean glandular fever or AI hepatitis, neither of which I have had, which leaves folks stumped. Looking forward to discussing this further should I ever get to see a CRPS specialist.

  2. God bless you for the work you are doing! I have CRPS and cannot function every day due to the pain. I’ve lost so much because of this disease……

    People like you are our only hope.

  3. Maria Anne Tripp Martinez says

    Thank you for sharing this invaluable information. It gives all of us with CRPS hope that a cure will be found for our pain.

  4. Clarissa Briggs says

    I’ve suffered this horrid Syndrome, CRPS, for 10 years. I’m really hoping more, much more research and answers can be given. I’d be happy to be part of trials to improve this monster!! Please don’t give up on us!
    Thank you

  5. Dr. Goebel- I’m currently receiving APherisis treatment for my dx of RSD/CRPS (right upper arm, possibly left arm, & consistent head tingles, burn, mild pain). I’ve done 7 weeks of Apherisis so far, i.e. 3 times/wk for 2 weeks, then 2 times/ wk for 5 weeks. Now I’ll be starting 1 time per week. I’m really not sure if there has been any lasting positive results. The two days after, I have those good days, when I could do some errands, etc. Can you help me understand the difference between intravenous immunoglobulin treatment, and the Aherisis treatment that I’m receiving??

  6. E M Christians says

    Dr Goebel, I commend you on your very enlightening article with regards to antibodies in those of us who suffer from CRPS; very well written and great documentation. Australian physicians are way ahead of the game when it comes to prioritizing pain conditions as your research stands for itself. In the states, there doesn’t appear to be a great interest in pursuing the many avenues of CRPS. Firstly, many MDs cannot even recognize or diagnose this condition. Secondly, those physicians in pain management seem to be satisfied with the present options for treatment which leaves us with very limited alternatives for pain alleviation.

    I would definitely like to see more research and studies regarding CRPS and its effect on the brain. At times, I’m not sure what is worse, the severe pain or memory lapses and/or loss of cognitive skills after having had CRPS for many years. Sometimes, I forget how to write my name and, as strange as this sounds, I’m now number dyslexic. I went from a medical office manager/hospital medical transcriptionist to a bumbling idiot at times. Extremely disheartening and a lot embarrassing.

    Thank you for all of your hard work and being an advocate for those of us with CRPS. May the Lord bless you and all of your future research. We are MORE than grateful to you for your continued pursuit in all realms of this devastating condition!

    E M

  7. Dr. Goebel, when people with CRPS become relatively asymptomatic, would it be correct in saying they are in remission? The terminology is important and I am struggling with it. Any help? Thanks.
    The reference to repeated transient stressors and autoimmunity is from Robert Sapolsky’s book ‘Why Zebras Don’t Get Ulcers’.

  8. Dr. Goebel, thanks for your tremendous research. I realize that you have identified alpha 1a autoantibodies as a contributing factor in CRPS – would the autoimmunity arise from repeated transient stressors that tip the person into autoimmunity? Is there a role of glucocorticoids vs IV IgG? It seems that there is a point in which things get ‘set-in’ with CRPS – further insight?Thanks again.

  9. Sandra Laxton says

    Thank you do much for working towards understanding this horrible disease. It’s so painful and disparaging to know that 24/7 you will be in pain with no hope for relief. God bless and I hope you continue with the research. The CRPS community would be eternally grateful. Thanks, Sandra Laxton

  10. Amelia Bland says

    I really hope it works, as I have suffered from CRPS for two years and it is so debilitating and destructive.

  11. Jennifer Picciotto says

    Thank you for your research and continuing advancement of our understanding of CRPS. I have read other research done by Dr. Goebel and admire your work. Much appreciated!