Research into the role of the brain and mind in chronic pain
Lorimer Moseley answering the question “What is the thing that annoys you most when we talk about back pain?”
Listen to Lorimer Moseley talk to Karim Khan on new understanding of pain and focusing on the patient.
The Body in Mind Research Group is based at The Sansom Institute for Health Research at the University of South Australia in Adelaide and Neuroscience Research Australia in Sydney. We have active collaborations with editors scattered around the world. Together we are seeking a better understanding of the interaction between the body, brain and mind in chronic and complex pain disorders.
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Further evidence to suggest we should learn something novel every decade
photo credit: CC Varios Autores Concurso de Fotografía científica
I remember sitting my folks down and sternly counselling them to make sure they learnt a completely novel skill once per decade, to ensure that their brain doesn’t turn to mush. There is plenty of evidence to support such advice (well, aside from the ‘mush’ bit), but here is a new finding that adds to that evidence, with a whole new level of detail. Xu et al from the Universities of Santa Cruz and Texas, in the USA, did an experiment with one month old mice. They taught the mice a task and then imaged their brains, at the level of individual dendrites. They showed that, within ONE HOUR of the training session, the mice who did well at the task (that is, had learnt it to some extent), had an increase in dendritic spines of about 10%. That is, the brain had undergone structural as well as functional changes. How cool is that?! One training session. What’s more, about 50% of the new spines were still there two weeks later and, for mice training for 16 days, 40% of the new spines were still there three months later. The authors conclude, and as far as I can tell it is a sensible conclusion,
Finally, they conclude their abstract, which is the bit that is meant to make the reader think this paper truly deserves its place in Nature, with this:
Of course, this study was done in mice. Surely, however, it lays the way for renewed attention to motor training in humans. In the wake of the Christmas/New Year DigestionFest, it is nice to have some food this time for thought.
Abstract
Rapid formation and selective stabilization of synapses for enduring motor memories
Tonghui Xu[1,3], Xinzhu Yu[1,3], Andrew J. Perlik[1], Willie F. Tobin[1], Jonathan A. Zweig[1], Kelly Tennant[2], Theresa Jones[2] & Yi Zuo [1]
1. Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
2. Institute for Neuroscience, Department of Psychology, University of Texas at Austin, Austin, Texas 78712, USA
3. These authors contributed equally to this work
Novel motor skills are learned through repetitive practice and, once acquired, persist long after training stops. Earlier studies have shown that such learning induces an increase in the efficacy of synapses in the primary motor cortex, the persistence of which is associated with retention of the task. However, how motor learning affects neuronal circuitry at the level of individual synapses and how long-lasting memory is structurally encoded in the intact brain remain unknown. Here we show that synaptic connections in the living mouse brain rapidly respond to motor-skill learning and permanently rewire……
See full article at Nature 462, 915-919
Lorimer Moseley (2010). Further evidence to suggest we should learn something novel every decade BodyinMind
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